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Sedating histamine

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" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.

This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.

This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.Celexa (Citalopram hydrobromide) was approved by the FDA in July 17, 1998.Celexa is manufactured by Forest Pharmaceuticals, Inc.The SSRIs represent the first rationally designed class of psychotropic medications.The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (eg, uptake pumps, receptors) while avoiding effects on other site of actions.Many people find the worst symptom of their eczema is severe itching.